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dc.contributor.authorVidela, Sebas-
dc.contributor.authorSirera, Guillem-
dc.contributor.authorLópez-Blázquez, Raquel-
dc.contributor.authorLlatjos, Mariona-
dc.contributor.authorTarrats, Antoni-
dc.contributor.authorCastellà, Eva-
dc.contributor.authorGrane, Nuria-
dc.contributor.authorAlcalde, Carme-
dc.contributor.authorTural, Cristina-
dc.contributor.authorRey-Joly, Celestino-
dc.contributor.authorClotet i Sala, Bonaventura-
dc.description.abstractThe influence of HAART on the evolution to cervical squamous intraepithelial lesions (SIL) among HIV(+) women with a normal cytological test in the HAART era was studied. A retrospective cohort study (1997-2005) of HIV-infected women treated with HAART was conducted. Those with a normal cervical cytology (Papanicolaou test) and at least one subsequent test were included. Survival (time until diagnosis of SIL), univariate, and multivariate analyses were performed. A total of 133 HIV-infected patients treated with HAART were included. The incidence of SIL was 35% (47 patients). SIL was diagnosed in 36 of 110 (33%) patients with a baseline and final immunological status of >200 CD4 cells/microl and in 6 of 9 (67%) patients with a baseline and final immunological status of < or =200 CD4 (OR: 0.24, 95% CI: 0.06-1.03, p = 0.041). SIL was diagnosed in 10 of 60 (17%) patients with an undetectable baseline and final HIV viral load and in 36 of 70 (51%) patients with a detectable HIV viral load (OR: 0.19, 95% CI: 0.07-0.46, p < 0.001). A high incidence of SIL (cancer precursor lesions) was observed among HIV(+) women without a background of cervical pathology. The effect of HAART on the control of HIV replication and of immunological status (>200 CD4) through the follow-up was associated with a reduction of SIL.-
dc.format.extent7 p.-
dc.publisherMary Ann Liebert-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofAids Research and Human Retroviruses, 2007, vol. 23, num. 8, p. 965-971-
dc.rights(c) Mary Ann Liebert, 2007-
dc.subject.classificationColl uterí-
dc.subject.classificationVIH (Virus)-
dc.subject.otherAntiretroviral agents-
dc.subject.otherCervix uteri-
dc.subject.otherHIV (Viruses)-
dc.titleEvolution of cervical cytologic changes among HIV-infected women with normal cytology in the HAART era.-
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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