Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/182396
Title: | Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors |
Author: | Llenas, Marina Paoli, Roberto Feiner Gràcia, Natalia Albertazzi, Lorenzo Samitier i Martí, Josep Caballero Vila, David |
Keywords: | Tumors Vasos sanguinis Tumors Blood vessels |
Issue Date: | 9-Jun-2021 |
Publisher: | MDPI |
Abstract: | Tumor vessel-on-a-chip systems have attracted the interest of the cancer research community due to their ability to accurately recapitulate the multiple dynamic events of the metastatic cascade. Vessel-on-a-chip microfluidic platforms have been less utilized for investigating the distinctive features and functional heterogeneities of tumor-derived vascular networks. In particular, vascular tumors are characterized by the massive formation of thrombi and severe bleeding, a rare and life-threatening situation for which there are yet no clear therapeutic guidelines. This is mainly due to the lack of technological platforms capable of reproducing these characteristic traits of the pathology in a simple and well-controlled manner. Herein, we report the fabrication of a versatile tumor vessel-on-a-chip platform to reproduce, investigate, and characterize the massive formation of thrombi and hemorrhage on-chip in a fast and easy manner. Despite its simplicity, this method offers multiple advantages to recapitulate the pathophysiological events of vascular tumors, and therefore, may find useful applications in the field of vascular-related diseases, while at the same time being an alternative to more complex approaches. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/bioengineering8060081 |
It is part of: | Bioengineering, 2021, vol. 8, num. 6 |
URI: | http://hdl.handle.net/2445/182396 |
Related resource: | https://doi.org/10.3390/bioengineering8060081 |
DOI: | https://doi.org/10.3390/bioengineering8060081 |
ISSN: | 2306-5354 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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bioengineering-08-00081-v2.pdf | 19.41 MB | Adobe PDF | View/Open |
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