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Title: | New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis |
Author: | Pérez-González, Noelia Bozal de Febrer, Núria Calpena Campmany, Ana Cristina Nardi Ricart, Anna Rodríguez Lagunas, María José Morales-Molina, José A. Soriano-Ruiz, José L. Fernández Campos, Francisco Clares Naveros, Beatriz |
Keywords: | Candidiasi Malalties de l'aparell genital femení Medicaments antifúngics Candidiasis Female reproductive system diseases Antifungal agents |
Issue Date: | 12-Dec-2021 |
Abstract: | Vulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of Candida spp. was also evaluated. In addition, tolerance of formulations was studied by histological analysis. Results confirmed that CSP hydrogels could be proposed as promising candidates for the treatment of VVC |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/gels7040259 |
It is part of: | Gels, 2021, num. 7, p. 259 |
URI: | http://hdl.handle.net/2445/183031 |
Related resource: | https://doi.org/10.3390/gels7040259 |
ISSN: | 2310-2861 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Bioquímica i Fisiologia) |
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