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http://hdl.handle.net/2445/185198
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DC Field | Value | Language |
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dc.contributor.author | Monelli, Erika | - |
dc.contributor.author | Villacampa, Pilar | - |
dc.contributor.author | Zabala Letona, Amaia | - |
dc.contributor.author | Martínez Romero, Anabel | - |
dc.contributor.author | Llena, Judith | - |
dc.contributor.author | Beiroa, Daniel | - |
dc.contributor.author | Gouveia, Leonor | - |
dc.contributor.author | Chivite, Iñigo | - |
dc.contributor.author | Zagmutt Caroxa, Sebastián | - |
dc.contributor.author | Gama-Perez, Pau | - |
dc.contributor.author | Osorio Conles, Óscar | - |
dc.contributor.author | Muixí, Laia | - |
dc.contributor.author | Martínez-González, Ainara | - |
dc.contributor.author | Castillo, Sandra D. | - |
dc.contributor.author | Martín-Martín, Natalia | - |
dc.contributor.author | Castel Morales, Pau | - |
dc.contributor.author | Valcárcel-Jiménez, Lorea | - |
dc.contributor.author | García-González, Irene | - |
dc.contributor.author | Villena, Josep A. | - |
dc.contributor.author | Fernández Ruiz, Sonia | - |
dc.contributor.author | Serra i Cucurull, Dolors | - |
dc.contributor.author | Herrero Rodríguez, Laura | - |
dc.contributor.author | Benedito, Rui | - |
dc.contributor.author | García-Roves, Pablo M. (Pablo Miguel) | - |
dc.contributor.author | Vidal, Josep | - |
dc.contributor.author | Cohen, Paul | - |
dc.contributor.author | Nogueiras, Rubén | - |
dc.contributor.author | Claret i Carles, Marc | - |
dc.contributor.author | Carracedo, Arkaitz | - |
dc.contributor.author | Graupera i Garcia-Milà, Mariona | - |
dc.date.accessioned | 2022-04-28T13:50:44Z | - |
dc.date.available | 2023-07-01T05:10:22Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2522-5812 | - |
dc.identifier.uri | http://hdl.handle.net/2445/185198 | - |
dc.description.abstract | Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of angiogenesis upon WAT expansion, a process that is impaired in obesity. However, the molecular mechanisms underlying the crosstalk between ECs and adipocytes remain poorly understood. Here, we show that local production of polyamines in ECs stimulates adipocyte lipolysis and regulates WAT homeostasis in mice. We promote enhanced cell-autonomous angiogenesis by deleting Pten in the murine endothelium. Endothelial Pten loss leads to a WAT-selective phenotype, characterized by reduced body weight and adiposity in pathophysiological conditions. This phenotype stems from enhanced fatty acid β-oxidation in ECs concomitant with a paracrine lipolytic action on adipocytes, accounting for reduced adiposity. Combined analysis of murine models, isolated ECs and human specimens reveals that WAT lipolysis is mediated by mTORC1-dependent production of polyamines by ECs. Our results indicate that angiocrine metabolic signals are important for WAT homeostasis and organismal metabolism. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: | - |
dc.relation.ispartof | Nature Metabolism, 2022 | - |
dc.rights | (c) Monelli, Erika et al., 2022 | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Teixit adipós | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Angiogènesi | - |
dc.subject.classification | Metabolisme | - |
dc.subject.other | Adipose tissues | - |
dc.subject.other | Obesity | - |
dc.subject.other | Neovascularization | - |
dc.subject.other | Metabolism | - |
dc.title | Angiocrine polyamines production regulates adiposity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 720145 | - |
dc.date.updated | 2022-04-28T13:50:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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720145.pdf | 425.74 kB | Adobe PDF | View/Open |
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