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http://hdl.handle.net/2445/186494
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DC Field | Value | Language |
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dc.contributor.author | Massot Cladera, Malen | - |
dc.contributor.author | Rigo Adrover, Maria del Mar | - |
dc.contributor.author | Herrero Rodríguez, Laura | - |
dc.contributor.author | Franch i Masferrer, Àngels | - |
dc.contributor.author | Castell, Margarida | - |
dc.contributor.author | Vulevic, Jelena | - |
dc.contributor.author | Pérez-Cano, Francisco J. | - |
dc.contributor.author | Rodríguez Lagunas, María José | - |
dc.date.accessioned | 2022-06-09T11:32:55Z | - |
dc.date.available | 2022-06-09T11:32:55Z | - |
dc.date.issued | 2022-05-18 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186494 | - |
dc.description.abstract | The leading cause of gastroenteritis among young children worldwide is the Group A rotaviruses (RV), which produce a wide range of symptoms, from a limited diarrhea to severe dehydration and even death. After an RV infection, immunity is not complete and less severe re-infections usually occur. These infections could be ameliorated by nutritional interventions with bioactive compounds, such as prebiotics. The aim of this research was to study the impact of a particular galactooligosaccharide (B-GOS) on the RV symptomatology and immune response during two consecutive infections. Lewis neonatal rats were inoculated with SA11 (first RV infection) on day 6 of life and with EDIM (second RV infection) on day 17 of life. B-GOS group was administered by oral gavage with a daily dose of B-GOS between days three to nine of life. Clinical and immunological variables were assessed during both infective processes. In the first infection, after the prebiotic intervention with B-GOS, a lower incidence, duration, and overall severity of the diarrhea (p < 0.05) was observed. In addition, it improved another severity indicator, the fecal weight output, during the diarrhea period (p < 0.05). The second RV infection failed in provoking diarrhea in the groups studied. The immune response during first infection with SA11 was not affected by B-GOS administration and had no impact on second infection, but the prebiotic intervention significantly increased IFN-γ and TNF-α intestinal production after the second infection (p < 0.05). In summary, B-GOS supplementation is able to reduce the incidence and severity of the RV-associated diarrhea and to influence the immune response against RV infections. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cells11101669 | - |
dc.relation.ispartof | Cells, 2022 | - |
dc.relation.uri | https://doi.org/10.3390/cells11101669 | - |
dc.rights | cc-by (c) Massot Cladera, Malen et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Diarrea | - |
dc.subject.classification | Prebiòtics | - |
dc.subject.classification | Malalties intestinals | - |
dc.subject.other | Diarrhea | - |
dc.subject.other | Prebiotics | - |
dc.subject.other | Intestinal diseases | - |
dc.title | A Galactooligosaccharide Product Decreases the Rotavirus Infection in Suckling Rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 723599 | - |
dc.date.updated | 2022-06-09T11:32:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
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File | Description | Size | Format | |
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723599.pdf | 2.48 MB | Adobe PDF | View/Open |
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