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dc.contributor.authorPlaninc, Ivo-
dc.contributor.authorGarcia Canadilla, Patricia-
dc.contributor.authorDejea, Hector-
dc.contributor.authorIlic, Ivana-
dc.contributor.authorGuasch i Casany, Eduard-
dc.contributor.authorZamora, Monica-
dc.contributor.authorCrispi Brillas, Fàtima-
dc.contributor.authorStampanoni, Marco-
dc.contributor.authorMilicic, Davor-
dc.contributor.authorBijnens, Bart-
dc.contributor.authorBonnin, Anne-
dc.contributor.authorCikes, Maja-
dc.description.abstractCardiovascular research is in an ongoing quest for a superior imaging method to integrate grossanatomical information with microanatomy, combined with quantifable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in detail. The objective was to use X-PCI to comprehensively quantify ischemic remodeling of diferent myocardial structures, from cell to organ level, in a rat model of myocardial infarction. Myocardial infarction-induced remodeling was recreated in a well-established rodent model. Ex vivo rodent hearts were imaged by propagation based X-PCI using two confgurations resulting in 5.8 µm and 0.65 µm efective pixel size images. The acquired datasets were used for a comprehensive assessment of macrostructural changes including the whole heart and vascular tree morphology, and quantifcation of left ventricular myocardial thickness, mass, volume, and organization. On the meso-scale, tissue characteristics were explored and compared with histopathological methods, while microstructural changes were quantifed by segmentation of cardiomyocytes and calculation of cross-sectional areas. Propagation based X-PCI provides detailed visualization and quantifcation of morphological changes on whole organ, tissue, vascular as well as individual cellular level of the ex vivo heart, with a single, non-destructive 3D imaging modality.-
dc.format.extent13 p.-
dc.publisherNature Publishing Group-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofScientific Reports, 2021, vol. 11, p. 14020-
dc.rightscc-by (c) Planinc, Ivo et al., 2021-
dc.subject.classificationDiagnòstic per la imatge-
dc.subject.classificationRaigs X-
dc.subject.otherDiagnostic imaging-
dc.titleComprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging.-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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