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http://hdl.handle.net/2445/186967
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DC Field | Value | Language |
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dc.contributor.author | Planinc, Ivo | - |
dc.contributor.author | Garcia Canadilla, Patricia | - |
dc.contributor.author | Dejea, Hector | - |
dc.contributor.author | Ilic, Ivana | - |
dc.contributor.author | Guasch i Casany, Eduard | - |
dc.contributor.author | Zamora, Monica | - |
dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.contributor.author | Stampanoni, Marco | - |
dc.contributor.author | Milicic, Davor | - |
dc.contributor.author | Bijnens, Bart | - |
dc.contributor.author | Bonnin, Anne | - |
dc.contributor.author | Cikes, Maja | - |
dc.date.accessioned | 2022-06-23T15:08:49Z | - |
dc.date.available | 2022-06-23T15:08:49Z | - |
dc.date.issued | 2021-01-07 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186967 | - |
dc.description.abstract | Cardiovascular research is in an ongoing quest for a superior imaging method to integrate grossanatomical information with microanatomy, combined with quantifable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in detail. The objective was to use X-PCI to comprehensively quantify ischemic remodeling of diferent myocardial structures, from cell to organ level, in a rat model of myocardial infarction. Myocardial infarction-induced remodeling was recreated in a well-established rodent model. Ex vivo rodent hearts were imaged by propagation based X-PCI using two confgurations resulting in 5.8 µm and 0.65 µm efective pixel size images. The acquired datasets were used for a comprehensive assessment of macrostructural changes including the whole heart and vascular tree morphology, and quantifcation of left ventricular myocardial thickness, mass, volume, and organization. On the meso-scale, tissue characteristics were explored and compared with histopathological methods, while microstructural changes were quantifed by segmentation of cardiomyocytes and calculation of cross-sectional areas. Propagation based X-PCI provides detailed visualization and quantifcation of morphological changes on whole organ, tissue, vascular as well as individual cellular level of the ex vivo heart, with a single, non-destructive 3D imaging modality. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-93054-6 | - |
dc.relation.ispartof | Scientific Reports, 2021, vol. 11, p. 14020 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-021-93054-6 | - |
dc.rights | cc-by (c) Planinc, Ivo et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Diagnòstic per la imatge | - |
dc.subject.classification | Raigs X | - |
dc.subject.classification | Animals | - |
dc.subject.other | Diagnostic imaging | - |
dc.subject.other | X-rays | - |
dc.subject.other | Animals | - |
dc.title | Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 721780 | - |
dc.date.updated | 2022-06-23T15:08:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34234175 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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721780.pdf | 2.43 MB | Adobe PDF | View/Open |
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