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Title: | Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora |
Author: | Pellegrini, Pasquale Hervera Abad, Arnau Varea, Olga Brewer, M. Kathryn López-Soldado, Iliana Guitart, Anna Aguilera, Mònica Prats, Neus Río Fernández, José Antonio del Guinovart, Joan J. (Joan Josep), 1947- Duran, Jordi |
Keywords: | Glicogen Epilèpsia Glycogen Epilepsy |
Issue Date: | 28-Dec-2021 |
Publisher: | Humana Press. |
Abstract: | Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates-the so-called Lafora Bodies (LBs)-in several organs. The accumulation of LBs in the brain underlies the neurological phenotype of the disease. LBs are composed of abnormal glycogen and various associated proteins, including p62, an autophagy adaptor that participates in the aggregation and clearance of misfolded proteins. To study the role of p62 in the formation of LBs and its participation in the pathology of LD, we generated a mouse model of the disease (malinKO) lacking p62. Deletion of p62 prevented LB accumulation in skeletal muscle and cardiac tissue. In the brain, the absence of p62 altered LB morphology and increased susceptibility to epilepsy. These results demonstrate that p62 participates in the formation of LBs and suggest that the sequestration of abnormal glycogen into LBs is a protective mechanism through which it reduces the deleterious consequences of its accumulation in the brain. |
Note: | Reproducció del document publicat a: https://doi.org/10.1007/s12035-021-02682-6 |
It is part of: | Molecular Neurobiology, 2021, vol. 59, num. 2, p. 1214-1229 |
URI: | http://hdl.handle.net/2445/189692 |
Related resource: | https://doi.org/10.1007/s12035-021-02682-6 |
ISSN: | 0893-7648 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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