Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/192561
Title: Grape polyphenols decrease circulating branched chain amino acids in overfed adults
Author: Bartova, Simona
Madrid Gambín, Francisco Javier
Fernández Romero, Luis
Carayol, Jerome
Meugnier, Emmanuelle
Segrestin, Bérénice
Delage, Pauline
Vionnet, Nathalie
Boizot, Alexia
Laville, Martine
Vidal, Hubert
Marco Colás, Santiago
Hager, Jörg
Moco, Sofia
Keywords: Seqüència d'aminoàcids
Polifenols
Obesitat
Metabolòmica
Metabolisme
Amino acid sequence
Polyphenols
Obesity
Metabolomics
Metabolism
Issue Date: 26-Oct-2022
Publisher: Frontiers Media
Abstract: Introduction and aims: Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials. Methods: Blood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape polyphenol extract or a placebo at 0, 15, 21, and 31 days were analyzed (Lyon study). Samples from a similarly designed trial on females (20 subjects) were collected in parallel (Lausanne study). Nuclear magnetic resonance (NMR)-based metabolomics was conducted to characterize metabolome changes induced by overfeeding and associated effects from polyphenol supplementation. The clinical trials are registered under the numbers NCT02145780 and NCT02225457 at ClinicalTrials.gov. Results: Changes in plasma levels of many metabolic markers, including branched chain amino acids (BCAA), ketone bodies and glucose in both placebo as well as upon polyphenol intervention were identified in the Lyon study. Polyphenol supplementation counterbalanced levels of BCAA found to be induced by overfeeding. These results were further corroborated in the Lausanne female study.Conclusion: Administration of grape polyphenol-rich extract over 1 month period was associated with a protective metabolic effect against overfeeding in adults.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fnut.2022.998044
It is part of: Frontiers In Nutrition, 2022, vol. 9, p. 998044
URI: http://hdl.handle.net/2445/192561
Related resource: https://doi.org/10.3389/fnut.2022.998044
ISSN: 2296-861X
Appears in Collections:Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)

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