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http://hdl.handle.net/2445/194013
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DC Field | Value | Language |
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dc.contributor.author | Di Pede, Giuseppe | - |
dc.contributor.author | Mena, Pedro | - |
dc.contributor.author | Bresciani, Letizia | - |
dc.contributor.author | Achour, Mariem | - |
dc.contributor.author | Lamuela Raventós, Rosa Ma. | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Landberg, Rikard | - |
dc.contributor.author | Kulling, Sabine | - |
dc.contributor.author | Wishart, David S. | - |
dc.contributor.author | Rodríguez-Mateos, Ana | - |
dc.contributor.author | Crozier, Alan | - |
dc.contributor.author | Manach, Claudine | - |
dc.contributor.author | Del Rio, Daniele | - |
dc.date.accessioned | 2023-02-23T10:18:27Z | - |
dc.date.available | 2023-02-23T10:18:27Z | - |
dc.date.issued | 2023-02-01 | - |
dc.identifier.issn | 0098-2997 | - |
dc.identifier.uri | http://hdl.handle.net/2445/194013 | - |
dc.description.abstract | This systematic review summarizes findings from human studies investigating the different routes of absorption, metabolism, distribution and excretion (ADME) of dietary flavan-3-ols and their circulating metabolites in healthy subjects. Literature searches were performed in PubMed, Scopus and the Web of Science. Human intervention studies using single and/or multiple intake of flavan-3-ols from food, extracts, and pure compounds were included. Forty-nine human intervention studies met inclusion criteria. Up to 180 metabolites were quantified from blood and urine samples following intake of flavan-3-ols, mainly as phase 2 conjugates of microbial catabolites (n =97), with phenyl-γ-valerolactones being the most representative ones (n =34). Phase 2 conjugates of monomers and phenyl-γ-valerolactones, the main compounds in both plasma and urine, reached two peak plasma concentrations (Cmax) of 260 and 88 nmol/L at 1.8 and 5.3 h (Tmax) after flavan-3-ol intake. They contributed to the bioavailability of flavan-3-ols for over 20%. Mean bioavailability for flavan-3-ols was moderate (31 ±23%, n bioavailability values =20), and it seems to be scarcely affected by the amount of ingested compounds. While intra- and inter-source differences in flavan-3-ol bioavailability emerged, mean flavan-3-ol bioavailability was 82% (n =1) and 63% (n =2) after ()-epicatechin and nut (hazelnuts, almonds) intake, respectively, followed by 25% after consumption of tea (n =7), cocoa (n =5), apples (n =3) and grape (n =2). This highlights the need to better clarify the metabolic yield with which monomer flavan-3-ols and proanthocyanidins are metabolized in humans. This work clarified in a comprehensive way for the first time the ADME of a (poly)phenol family, highlighting the pool of circulating compounds that might be determinants of the putative beneficial effects linked to flavan-3-ol intake. Lastly, methodological inputs for implementing well- designed human and experimental model studies were provided. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.mam.2022.101146 | - |
dc.relation.ispartof | Molecular Aspects of Medicine, 2023, vol. 89 | - |
dc.relation.uri | https://doi.org/10.1016/j.mam.2022.101146 | - |
dc.rights | cc-by-nc-nd (c) Giuseppe Di Pede, et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Compostos bioactius | - |
dc.subject.classification | Flavonoides | - |
dc.subject.other | Bioactive compounds | - |
dc.subject.other | Flavonoids | - |
dc.title | Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 729945 | - |
dc.date.updated | 2023-02-23T10:18:27Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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729945.pdf | 5.6 MB | Adobe PDF | View/Open |
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