Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/195265
Title: | Visceral Adipose Tissue Phospholipid Signature of Insulin Sensitivity and Obesity |
Author: | Palau-Rodriguez, Magalí Marco-Ramell, Anna Casas-Agustench, Patricia Tulipani, Sara Miñarro Alonso, Antonio Sànchez, Àlex (Sànchez Pla) Murri, Mora Tinahones, Francisco J. Andrés Lacueva, Ma. Cristina |
Keywords: | Fenotip Resistència a la insulina Metabolòmica Fosfolípids Obesitat Diabetis Phenotype Insulin resistance Metabolomics Phospholipids Obesity Diabetes |
Issue Date: | 1-May-2021 |
Publisher: | American Chemical Society |
Abstract: | Alterations in visceral adipose tissue (VAT) are closely linked to cardiometabolic abnormalities. The aim of this work is to define a metabolic signature in VAT of insulin resistance (IR) dependent on, and independent of, obesity. An untargeted UPLC-Q-Exactive metabolomic approach was carried out on the VAT of obese insulin-sensitive (IS) and insulinresistant subjects (N = 11 and N = 25, respectively) and nonobese IS and IR subjects (N = 25 and N = 10, respectively). The VAT metabolome in obesity was defined among other things by changes in the metabolism of lipids, nucleotides, carbohydrates, and amino acids, whereas when combined with high IR, it affected the metabolism of 18 carbon fatty acyl-containing phospholipid species. A multimetabolite model created by glycerophosphatidylinositol (18:0); glycerophosphatidylethanolamine (18:2); glycerophosphatidylserine (18:0); and glycerophosphatidylcholine (18:0/18:1), (18:2/18:2), and (18:2/18:3) exhibited a highly predictive performance to identify the metabotype of 'insulin-sensitive obesity' among obese individuals [area under the curve (AUC) 96.7% (91.9−100)] and within the entire study population [AUC 87.6% (79.0−96.2)]. We demonstrated that IR has a unique and shared metabolic signature dependent on, and independent of, obesity. For it to be used in clinical practice, these findings need to be validated in a more accessible sample, such as blood. |
Note: | Reproducció del document publicat a: https://doi.org/10.1021/acs.jproteome.0c00918 |
It is part of: | Journal of Proteome Research, 2021, vol. 20, num. 5, p. 2410-2419 |
URI: | http://hdl.handle.net/2445/195265 |
Related resource: | https://doi.org/10.1021/acs.jproteome.0c00918 |
ISSN: | 1535-3893 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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