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http://hdl.handle.net/2445/197285
Title: | A green and cost-effective approach for the efficient conversion of grape byproducts into innovative delivery systems tailored to ensure intestinal protection and gut microbiota fortification |
Author: | Perra, Matteo Manca, Maria Letizia Tuberoso, Carlo I.G. Caddeo, Carla Marongiu, Francesca Peris, Josè Esteban Orrù, Germano Ibba, Antonella Fernàndez Busquets, Xavier Fattouch, Sami Bacchetta, Gianluigi Manconi, Maria |
Keywords: | Probiòtics Raïms Probiotics Grapes |
Issue Date: | 1-Aug-2022 |
Publisher: | Elsevier |
Abstract: | According to circular economy, wine-making by-products represent a fascinating biomass, which can be used for the sustainable exploitation of polyphenols and the development of new nanotechnological health-promoting products. In this study, polyphenols contained in the grape pomace were extracted by maceration with ethanol in an easy and low dissipative way. The obtained extract, rich in malvidin-3-glucoside, quercetin, procyanidin B2 and gallic acid, was incorporated into phospholipid vesicles tailored for intestinal delivery. To improve their performances, vesicles were enriched with gelatine or a maltodextrin (Nutriose®), or their combination (gelatine-liposomes, nutriosomes and gelatine-nutriosomes). The small (~147 nm) and negatively charged (~ −50 mV) vesicles were stable at different pH values mimicking saliva (6.75), gastric (1.20) and intestinal (7.00) environments. Vesicles effectively protected intestinal cells (Caco-2) from the oxidative stress and promoted the biofilm formation by probiotic bacteria. A preliminary evaluation of the vesicle feasibility at industrial levels was also performed, analysing the economic and energetic costs needed for their production. |
Note: | Postprint del document publicat a: https://doi.org/10.1016/j.ifset.2022.103103 |
It is part of: | Innovative Food Science and Emerging Technologies, 2022, vol. 80 |
URI: | http://hdl.handle.net/2445/197285 |
Related resource: | https://doi.org/10.1016/j.ifset.2022.103103 |
ISSN: | 1878-5522 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (ISGlobal) |
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