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http://hdl.handle.net/2445/197660| Title: | Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation |
| Author: | Ortiz-Maldonado Gibson, Valentín Frigola, Gerard Español Rego, Marta Balagué, Olga Martínez Cibrian, Nuria Magnano, Laura Giné Soca, Eva Pascal i Capdevila, Mariona Correa, Juan G. Martínez Roca, Alexandra Cid, Joan Lozano Molero, Miguel Villamor i Casas, Neus Benitez Ribas, Daniel Esteve Comas, Jordi López Guillermo, Armando Campo Güerri, Elias Urbano Ispizua, Álvaro Juan, Manel Delgado, Julio (Delgado González) |
| Keywords: | Leucèmia limfocítica crònica Teràpia cel·lular Chronic lymphocytic leukemia Cellular therapy |
| Issue Date: | 31-Jan-2022 |
| Abstract: | CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade ≥3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high risk CLL or RT |
| Note: | Reproducció del document publicat a: https://doi.org/10.3389/fonc.2022.828471 |
| It is part of: | Frontiers In Oncology, 2022, vol.12, num. 828471 |
| URI: | http://hdl.handle.net/2445/197660 |
| Related resource: | https://doi.org/10.3389/fonc.2022.828471 |
| ISSN: | 2234-943X |
| Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia_FrontiersInOncology.pdf | 5.71 MB | Adobe PDF | View/Open |
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