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http://hdl.handle.net/2445/198757
Title: | Effect of surface functionalization and loading on the mechanical properties of soft polymeric nanoparticles prepared by nano-emulsion templating |
Author: | Dols Perez, Aurora Fornaguera, Cristina Feiner Gracia, Natalia Grijalvo, Santiago Solans, Conxita Gomila Lluch, Gabriel |
Keywords: | Nanomedicina Nanopartícules Propietats mecàniques Nanomedicine Nanoparticles Mechanical properties |
Issue Date: | 12-Nov-2022 |
Publisher: | Elsevier B.V. |
Abstract: | Drug and gene delivery systems based on polymeric nanoparticles offer a greater efficacy and a reduced toxicity compared to traditional formulations. Recent studies have evidenced that their internalization, biodistribution and efficacy can be affected, among other factors, by their mechanical properties. Here, we analyze by means of Atomic Force Microscopy force spectroscopy how composition, surface functionalization and loading affect the mechanics of nanoparticles. For this purpose, nanoparticles made of Poly(lactic-co-glycolic) (PLGA) and Ethyl cellulose (EC) with different functionalizations and loading were prepared by nano-emulsion templating using the Phase Inversion Composition method (PIC) to form the nano-emulsions. A multiparametric nanomechanical study involving the determination of the Young's modulus, maximum deformation and breakthrough force was carried out. The obtained results showed that composition, surface functionalization and loading affect the nanomechanical properties in a different way, thus requiring, in general, to consider the overall mechanical properties after the addition of a functionalization or loading. A graphical representation method has been proposed enabling to easily identify mechanically equivalent formulations, which is expected to be useful in the development of soft polymeric nanoparticles for pre-clinical and clinical use |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.colsurfb.2022.113019 |
It is part of: | Colloids and Surfaces B-Biointerfaces, vol. 222, p. 113019, February 2023 |
URI: | http://hdl.handle.net/2445/198757 |
Related resource: | https://doi.org/10.1016/j.colsurfb.2022.113019 |
ISSN: | 0927-7765 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) |
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File | Description | Size | Format | |
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729159.pdf | 7.1 MB | Adobe PDF | View/Open |
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