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Title: | Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity |
Author: | Carmona-Maurici, Júlia Rosa de la Cruz, Araceli Azcona-Granada, Natalia Peña, Elionora Ricart i Jané, David Viñas, Anna López Tejero, M. Dolores Domingo i Pedrol, Joan Carles Miñarro Alonso, Antonio Baena-Fustegueras, Juan Antonio Peinado Onsurbe, Julia Pardina Arrese, Eva |
Keywords: | Obesitat mòrbida Trastorns del metabolisme Aterosclerosi Morbid obesity Disorders of metabolism Atherosclerosis |
Issue Date: | 3-May-2023 |
Publisher: | MDPI |
Abstract: | Severe obesity (SO) can accelerate atherosclerosis and the onset of acute cardiovascular events. The diagnosis of atherosclerosis in the context of a high body mass index (BMI) can be challenging, making the identification of biomarkers clinically relevant. We aimed to assess the usefulness of irisin as a biomarker for subclinical atherosclerosis in participants with SO. This prospective observational study included 61 participants undergoing bariatric surgery for SO, defined as a BMI >40 kg/m2 or >35 kg/m2 with at least one comorbidity. Atherosclerotic plaques were detected by ultrasound. Plasma samples were obtained 1 month before and at 6 and 12 months after bariatric surgery to measure irisin by ELISA. Additionally, subcutaneous samples of adipose tissue were taken and genotyped to identify irisin polymorphism rs3480. Irisin levels were positively correlated with BMI (r = 0.23, p = 0.0064), negatively correlated with atheroma-related parameters (e.g., carotid intima-media thickness), and lower in subjects with atheroma (p < 0.0002). Irisin also showed good overall accuracy for discriminating plaque presence (AUC, 0.81; 95% CI, 0.6956-0.9156). However, the rs3480 polymorphism correlated with neither the irisin levels nor the presence of atheromas. Iirisin could identify subclinical atherosclerosis in SO and might facilitate clinical diagnosis. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms24098171 |
It is part of: | International Journal of Molecular Sciences, 2023, vol. 24, num. 9, p. 8171 |
URI: | http://hdl.handle.net/2445/198801 |
Related resource: | https://doi.org/10.3390/ijms24098171 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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