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http://hdl.handle.net/2445/198889
Title: | Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder |
Author: | Demontis, Ditte Walters, Raymond K. Martin, Joanna Mattheisen, Manuel Als, Thomas D. Agerbo, Esben Baldursson, Gísli Belliveau, Rich Bybjerg-Grauholm, Jonas Bækvad-Hansen, Marie Cerrato, Felicia Chambert, Kimberly Churchhouse, Claire Dumont, Ashley Eriksson, Nicholas Gandal, Michael Goldstein, Jacqueline I. Grasby, Katrina L. Grove, Jakob Gudmundsson, Olafur O. Hansen, Christine S. Hauberg, Mads Engel Hollegaard, Mads V. Howrigan, Daniel P. Huang, Hailiang Maller, Julian B. Martin, Alicia R. Martin, Nicholas G. Moran, Jennifer Pallesen, Jonatan Palmer, Duncan S. Pedersen, Carsten Bøcker Pedersen, Marianne Giørtz Poterba, Timothy Poulsen, Jesper Buchhave Ripke, Stephan Robinson, Elise B. Satterstrom, F. Kyle Stefansson, Hreinn Stevens, Christine Turley, Patrick Walters, G. Bragi Won, Hyejung Wright, Margaret J. ADHD Working Group of the Psychiatric Genomics Consortium (PGC) Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium 23andMe Research Team Andreassen, Ole A. Asherson, Philip Burton, Christie L. Boomsma, Dorret I. Cormand Rifà, Bru Dalsgaard, Søren Franke, Barbara Gelernter, Joel Geschwind, Daniel Hakonarson, Hakon Haavik, Jan Kranzler, Henry R. Kuntsi, Joanna Langley, Kate Lesch, Klaus-Peter Middeldorp, Christel Reif, Andreas Rhode, Luis Augusto Roussos, Panos Schachar, Russell Sklar, Pamela Sonuga-Barke, Edmund J. S Sullivan, Patrick F. Thapar, Anita Tung, Joyce Y. Waldman, Irwin D. Medland, Sarah E. Stefansson, Kari Nordentoft, Merete Hougaard, David M. Werge, Thomas Mors, Ole Mortensen, Preben Bo Daly, Mark J. Faraone, Stephen V. Børglum, Anders D. Neale, Benjamin M. |
Keywords: | Trastorns per dèficit d'atenció amb hiperactivitat en els infants Trastorns per dèficit d'atenció amb hiperactivitat en els adults Genoma humà Attention deficit disorder with hyperactivity in children Attention deficit disorder with hyperactivity in adults Human genome |
Issue Date: | Jan-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/s41588-018-0269-7 |
It is part of: | Nature Genetics, 2019, vol. 51, num. 1, p. 63-75 |
URI: | http://hdl.handle.net/2445/198889 |
Related resource: | https://doi.org/10.1038/s41588-018-0269-7 |
ISSN: | 1061-4036 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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