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http://hdl.handle.net/2445/207373
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DC Field | Value | Language |
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dc.contributor.author | Lanuza, Fabian | - |
dc.contributor.author | Meroño, Tomás | - |
dc.contributor.author | Zamora-Ros, Raul | - |
dc.contributor.author | Bondonno, Nicola P. | - |
dc.contributor.author | Rostgaard-Hansen, Agnetha Linn | - |
dc.contributor.author | Sánchez Pla, Alex | - |
dc.contributor.author | Miró, Berta | - |
dc.contributor.author | Carmona Pontaque, Francesc | - |
dc.contributor.author | Riccardi, Gabriele | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Landberg, Rikard | - |
dc.contributor.author | Halkjær, Jytte | - |
dc.contributor.author | Andres-Lacueva, Cristina | - |
dc.date.accessioned | 2024-02-09T14:41:37Z | - |
dc.date.available | 2024-02-09T14:41:37Z | - |
dc.date.issued | 2023-09-08 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | http://hdl.handle.net/2445/207373 | - |
dc.description.abstract | Background and aims: Plant-based dietary patterns have been associated with improved health outcomes. This study aims to describe the metabolomic fingerprints of plant-based diet indices (PDI) and examine their association with metabolic syndrome (MetS) and its components in a Danish population. Methods: The MAX study comprised 676 participants (55% women, aged 18-67 y) from Copenhagen. Sociodemographic and dietary data were collected using questionnaires and three 24-h dietary recalls over one year (at baseline, and at 6 and 12 months). Mean dietary intakes were computed, as well as overall PDI, healthful (hPDI) and unhealthful (uPDI) scores, according to food groups for each plant-based index. Clinical variables were also collected at the same time points in a health examination that included complete blood tests. MetS was defined according to the International Diabetes Federation criteria. Plasma metabolites were measured using a targeted metabolomics approach. Metabolites associated with PDI were selected using random forest models and their relationships with PDIs and MetS were analyzed using generalized linear mixed models. Results: The mean prevalence of MetS was 10.8%. High, compared to low, hPDI and uPDI scores were associated with a lower and higher odd of MetS, respectively [odds ratio (95%CI); hPDI: 0.56 (0.43-0.74); uPDI: 1.61 (1.26-2.05)]. Out of 411 quantified plasma metabolites, machine-learning metabolomics fingerprinting revealed 13 metabolites, including food and food-related microbial metabolites, like hypaphorine, indolepropionic acid and lignan-derived enterolactones. These metabolites were associated with all PDIs and were inversely correlated with MetS components (p < 0.05). Furthermore, they had an explainable contribution of 12% and 14% for the association between hPDI or uPDI, respectively, and MetS only among participants with overweight/obesity. Conclusions: Metabolites associated with PDIs were inversely associated with MetS and its components, and may partially explain the effects of plant-based diets on cardiometabolic risk factors. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/https://doi.org/10.1016/j.atherosclerosis.2023.117285 | - |
dc.relation.ispartof | Atherosclerosis, 2023, vol. 382, 117285 | - |
dc.relation.uri | https://doi.org/https://doi.org/10.1016/j.atherosclerosis.2023.117285 | - |
dc.rights | cc-by (c) Lanuza et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Síndrome metabòlica | - |
dc.subject.classification | Dietoteràpia | - |
dc.subject.classification | Plasma sanguini | - |
dc.subject.other | Metabolic syndrome | - |
dc.subject.other | Diet therapy | - |
dc.subject.other | Blood plasma | - |
dc.title | Plasma metabolomic profiles of plant-based dietary indices reveal potential pathways for metabolic syndrome associations | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 740174 | - |
dc.date.updated | 2024-02-09T14:41:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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