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http://hdl.handle.net/2445/207639| Title: | Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease |
| Author: | Rodríguez Urgellés, Ened Casas Torremocha, Diana Sancho Balsells, Anna Ballasch, Ivan García-García, Esther Miquel Rio, Lluís Manasanch, Arnau Del Castillo, Ignacio Chen, Wanqi Pupak, Anika Brito, Verónica Tornero, Daniel Rodríguez Allué, Manuel José Bortolozzi, Analía Sánchez-Vives, María Victoria Giralt Torroella, Albert Alberch i Vié, Jordi |
| Keywords: | Corea de Huntington Hipotàlem Ganglis basals Neurones sensorials Electrofisiologia Huntington's chorea Hypothalamus Basal ganglia Sensory neurons Electrophysiology |
| Issue Date: | 21-Nov-2023 |
| Publisher: | Springer Verlag |
| Abstract: | Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1007/s00018-023-05015-z |
| It is part of: | Cellular and Molecular Life Sciences, 2023, vol. 80, num.12 |
| URI: | http://hdl.handle.net/2445/207639 |
| Related resource: | https://doi.org/10.1007/s00018-023-05015-z |
| DOI: | 10.1007/s00018-023-05015-z |
| ISSN: | 1420-682X |
| Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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