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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/20789
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dc.contributor.authorPalazón Barandela, Javiercat
dc.contributor.authorNavarro-Ocaña, Arturocat
dc.contributor.authorHernández-Vázquez, Lilianacat
dc.contributor.authorMirjalili, Mohammad Hosseincat
dc.date.accessioned2011-11-18T11:50:56Z-
dc.date.available2011-11-18T11:50:56Z-
dc.date.issued2008-08-18-
dc.identifier.issn1420-3049-
dc.identifier.urihttp://hdl.handle.net/2445/20789-
dc.description.abstractScopolamine is an alkaloid widely used in medicine for its anticholinergic activity. The aim of this review is to show that metabolic engineering techniques constitute a suitable tool to improve the production of tropane alkaloids, focusing in particular on scopolamine. We present an overview of results obtained by various research groups, including our own, who have studied the overexpression of genes involved in the biosynthesis of scopolamine in different plant species that produce tropane alkaloids. Experiments carried out to improve production in hairy root cultures will also be described, as well as those attempting to biotransform hyoscyamine into scopolamine in roots and transgenic tobacco cells.eng
dc.format.extent21 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoengeng
dc.publisherMDPI Publishingeng
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.3390/molecules13081722cat
dc.relation.ispartofMolecules 2008, 13(8), 1722-1742-
dc.relation.urihttp://dx.doi.org/10.3390/molecules13081722-
dc.rightscc-by, (c) Palazón et al., 2008-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Biologia, Sanitat i Medi Ambient)-
dc.subject.classificationAlcaloidescat
dc.subject.classificationEnginyeria bioquímicacat
dc.subject.otherAlkaloidseng
dc.subject.otherBiochemical engineeringeng
dc.titleApplication of metabolic engineering to the production of scopolamineeng
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec563422-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid18794782-
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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