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|Title:||Rat splanchnic net oxygen consumption. Energetic implications|
|Author:||Casado, Javier (Casado Merediz)|
Fernández López, José Antonio
Rafecas Jorba, Immaculada
Argilés Huguet, Josep Ma.
Alemany, Marià, 1946-
|Keywords:||Rates com animals de laboratori|
Rats as laboratory animals
|Publisher:||Cambridge University Press|
|Abstract:||1. The blood flow, PO2, pH and PCO2 have been estimated in portal and suprahepatic veins as well as in hepatic artery of fed and overnight starved rats given an oral glucose load. From these data the net intestinal, hepatic and splanchnic balances for oxygen and bicarbonate were calculated. The oxygen consumption of the intact animal has also been measured under comparable conditions. 2. The direct utilization of oxygen balances as energy equivalents when establishing the contribution of energy metabolism of liver and intestine to the overall energy expenses of the rat, has been found to be incorrect, since it incorporates the intrinsic error of interorgan proton transfer through bicarbonate. Liver and intestine produced high net bicarbonate balances in all situations tested, implying the elimination (by means of oxidative pathways, i.e. consuming additional oxygen) of high amounts of H+ generated with bicarbonate. The equivalence in energy output of the oxygen balances was then corrected for bicarbonate production to 11-54% lower values. 3. Intestine and liver consume a high proportion of available oxygen, about one-half in basal (fed or starved) conditions and about one-third after gavage, the intestine consumption being about 15% in all situations tested and the liver decreasing its oxygen consumption with gavage.|
|Note:||Reproducció del document publicat a: http://jp.physoc.org/content/431/1/557.abstract|
|It is part of:||Journal of Physiology-London, 1990, vol. 431, p. 557-569|
|Appears in Collections:||Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)|
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
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