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http://hdl.handle.net/2445/22228
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DC Field | Value | Language |
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dc.contributor.author | Cañas, Xavier | cat |
dc.contributor.author | Sanchis, D. | cat |
dc.contributor.author | Gómez, G. | cat |
dc.contributor.author | Casanovas, J.M. | cat |
dc.contributor.author | Artigas Pérez, Francesc | cat |
dc.contributor.author | Fernández López, José Antonio | cat |
dc.contributor.author | Remesar Betlloch, Xavier | cat |
dc.contributor.author | Alemany, Marià, 1946- | cat |
dc.date.accessioned | 2012-02-24T10:31:58Z | - |
dc.date.available | 2012-02-24T10:31:58Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0022-0949 | - |
dc.identifier.uri | http://hdl.handle.net/2445/22228 | - |
dc.description.abstract | Pentobarbital-anaesthetized male Wistar rats were infused with 6microgkg-1min-1 of noradrenaline. The infusion was supplemented with 8.5 mgkg-1min-1 of D-3-hydroxybutyrate (3-OHB) for 15 min in order to determine its effect on the adrenergic response of the rat. Plasma levels of noradrenaline rose to a plateau of approximately 50 nmoll-1 with infusion. In the group infused with noradrenaline alone, noradrenaline levels were maintained for 1h. Supplementation with 3-OHB induced a decrease in plasma noradrenaline level that was inversely correlated with 3-OHB level. Aortic and interscapular brown adipose tissue temperatures increased with noradrenaline infusion, but the rise was arrested by 3-OHB; replacing 3-OHB with glucose had no effect. Infusion of saline, glucose or 3-OHB in the absence of noradrenaline did not induce a rise in temperature in either tissue. Blood 3-OHB concentration increased to 1.2 mmoll-1 during 3-OHB infusion, decreasing rapidly at the end of infusion. Blood glucose levels increased with noradrenaline infusion; the presence of high 3-OHB levels decreased glucose concentration. The effects observed were transient and dependent on 3-OHB concentration; these effects may help explain most of the other effects of noradrenaline described here. The role of 3-OHB as a regulator of adrenergic responses seems to be part of a complex fail-safe mechanism which prevents wasting. | eng |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | eng |
dc.publisher | Company of Biologists Ltd. | - |
dc.relation.isformatof | Reproducció del document publicat a: http://jeb.biologists.org/content/200/20/2641.abstract | - |
dc.relation.ispartof | Journal of Experimental Biology, 1997, vol. 200, p. 2641-2646 | - |
dc.rights | (c) Company of Biologists Ltd., 1997 | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Metabolisme | cat |
dc.subject.classification | Nutrició | cat |
dc.subject.classification | Rates (Animals de laboratori) | cat |
dc.subject.other | Metabolism | eng |
dc.subject.other | Nutrition | eng |
dc.subject.other | Rats as laboratory animals | eng |
dc.title | 3-Hydroxybutyrate coinfused with noradrenaline decreases resulting plasma levels of noradrenaline in Wistar rats | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.identifier.idgrec | 137320 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
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137320.pdf | 166.72 kB | Adobe PDF | View/Open |
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