Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/32942
Title: Effect of a cocoa flavonoid-enriched diet on experimental autoimmune arthritis
Author: Ramos Romero, Sara
Pérez-Cano, Francisco J.
Pérez Berezo, Teresa
Castellote i Bargalló, M. Cristina
Franch i Masferrer, Àngels
Castell, Margarida
Keywords: Artritis
Immunoglobulines
Estrès oxidatiu
Flavonoides
Cacau
Limfòcits
Arthritis
Immunoglobulins
Oxidative stress
Flavonoids
Cocoa
Lymphocytes
Issue Date: 19-Jul-2011
Publisher: Cambridge University Press
Abstract: Previously we established that a cocoa-enriched diet in young rats reduces the specific antibody production and the Th lymphocyte proportion in lymphoid tissues. The aim of the present study was to ascertain the modulatory ability of a cocoa flavonoid enriched diet on collagen-induced arthritis (CIA), which is mediated by anti collagen autoantibody response and Th lymphocyte activation. Female LOU rats were fed with a cocoa enriched diet, beginning two weeks before CIA induction. The hind paw swelling and serum cytokine and anti collagen antibody concentrations were determined. Anti collagen antibody-secreting cell counts and lymphocyte subset proportions were established in inguinal lymph nodes. Reactive oxygen species (ROS), NO and TNFα by peritoneal macrophages were determined. Although arthritis cocoa-fed rats showed a similar hind-paw swelling time course as the arthritis animals fed a standard diet, the cocoa intake was able to decrease specific IgG2a, IgG2b, and IgG2c titres. Moreover, cocoa intake in CIA rats reduced ROS production, TNFα and NO release from peritoneal macrophages, and decreased the Th/Tc ratio in inguinal lymph nodes. In conclusion, a cocoa flavonoid-enriched diet in LOU rats with CIA produced no effect on hind-paw swelling but was able to modulate the specific antibody response and also the Th lymphocyte proportions, as well as the synthesis of pro-inflammatory mediators from peritoneal macrophages. Therefore, a cocoa-enriched diet could be a good adjuvant therapy in disorders with oxidative stress or autoimmune pathogenesis.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1017/S000711451100328X
It is part of: British Journal of Nutrition, 2011, vol. 107, num. 4, p. 523-532
Related resource: http://dx.doi.org/10.1017/S000711451100328X
URI: http://hdl.handle.net/2445/32942
ISSN: 0007-1145
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

Files in This Item:
File Description SizeFormat 
595665.pdf269.05 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.