Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/33013
Title: A diet enriched with cocoa prevents IgE synthesis in a rat allergy model
Author: Abril-Gil, Mar
Massot-Cladera, Malén
Pérez-Cano, Francisco J.
Castellote i Bargalló, M. Cristina
Franch i Masferrer, Àngels
Castell, Margarida
Keywords: Cacau
Flavonoides
Al·lèrgia
Rates (Animals de laboratori)
Resposta immunitària
Immunoglobulina E
Cocoa
Flavonoids
Allergy
Rats as laboratory animals
Immune response
Immunoglobulin E
Issue Date: Jun-2012
Publisher: Elsevier B.V.
Abstract: Previous studies in young rats reported the impact of cocoa intake on healthy immune status and allow suggesting it may have a role in the prevention of some immune-mediated diseases. The aim of this study was to ascertain the effect of a cocoa diet in a model of allergy in young rats. Three-week-old Brown Norway rats were immunized by i.p. injection of ovalbumin (OVA) with alum as adjuvant and Bordetella pertussis toxin. During the next 4 weeks rats received either a cocoa diet (containing 0.2% polyphenols, w/w) or a standard diet. Animals fed a standard diet showed high concentrations of anti-OVA IgG1, IgG2a, IgG2b and high anti-OVA IgE titres, which is the antibody involved in allergic response. In contrast, animals fed a cocoa diet showed significantly lower concentrations of anti-OVA IgG1 and IgG2a antibodies. Interestingly, the cocoa diet prevented anti-OVA IgE synthesis and decreased total serum IgE concentration. Analysis of cytokine production in lymph node cells at the end of the study revealed that, in this compartment, the cocoa diet decreased the tumor necrosis factor (TNF) - alpha and the interleukin (IL) -10 secretion but not IL-4 production. In conclusion, a cocoa-enriched diet in young rats produces an immunomodulatory effect that prevents anti-allergen IgE synthesis, suggesting a potential role for cocoa flavonoids in the prevention or treatment of allergic diseases.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.phrs.2012.02.001
It is part of: Pharmacological Research, 2012, vol. 65, num. 6, p. 603-608
Related resource: http://dx.doi.org/10.1016/j.phrs.2012.02.001
URI: http://hdl.handle.net/2445/33013
ISSN: 1043-6618
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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