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Title: Statistical properties of new neutrality tests against population growth.
Author: Ramos Onsins, Sebastián Ernesto
Rozas Liras, Julio A.
Keywords: ADN mitocondrial
Genètica de poblacions
Mitochondrial DNA
Population Genetics
Issue Date: 1-Dec-2002
Publisher: Oxford University Press
Abstract: A number of statistical tests for detecting population growth are described. We compared the statistical power of these tests with that of others available in the literature. The tests evaluated fall into three categories: those tests based on the distribution of the mutation frequencies, on the haplotype distribution, and on the mismatch distribution. We found that, for an extensive variety of cases, the most powerful tests for detecting population growth are Fu"s FS test and the newly developed R2 test. The behavior of the R2 test is superior for small sample sizes, whereas FS is better for large sample sizes. We also show that some popular statistics based on the mismatch distribution are very conservative. Key words: population growth, population expansion, coalescent simulations, neutrality tests
Note: Versió postprint del document publicat a:
It is part of: Molecular Biology and Evolution, 2002, vol. 19, num. 12, p. 2092-2100
ISSN: 0737-4038
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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