Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/36389
Title: Updating Farful Memories with Extinction Training during Reconsolidation: A Human Study Using Auditory Aversive Stimuli
Author: Oyarzún, Javiera P.
Lopez-Barroso, Diana
Fuentemilla Garriga, Lluís
Cucurell, David
Pedraza, Carmen
Rodríguez Fornells, Antoni
Diego Balaguer, Ruth de
Keywords: Trastorn per estrès posttraumàtic
Trastorns auditius
Estudi de casos
Post-traumatic stress disorder
Hearing disorders
Case studies
Issue Date: 2012
Publisher: Public Library of Science (PLoS)
Abstract: Learning to fear danger in the environment is essential to survival, but dysregulation of the fear system is at the core of many anxiety disorders. As a consequence, a great interest has emerged in developing strategies for suppressing fear memories in maladaptive cases. Recent research has focused in the process of reconsolidation where memories become labile after being retrieved. In a behavioral manipulation, Schiller et al., (2010) reported that extinction training, administrated during memory reconsolidation, could erase fear responses. The implications of this study are crucial for the possible treatment of anxiety disorders without the administration of drugs. However, attempts to replicate this effect by other groups have been so far unsuccessful. We sought out to reproduce Schiller et al., (2010) findings in a different fear conditioning paradigm based on auditory aversive stimuli instead of electric shock. Following a within-subject design, participants were conditioned to two different sounds and skin conductance response (SCR) was recorded as a measure of fear. Our results demonstrated that only the conditioned stimulus that was reminded 10 minutes before extinction training did not reinstate a fear response after a reminder trial consisting of the presentation of the unconditioned stimuli. For the first time, we replicated Schiller et al., (2010) behavioral manipulation and extended it to an auditory fear conditioning paradigm.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0038849
It is part of: PLoS One, 2012, vol. 7, num. 6, p. e38849
Related resource: http://dx.doi.org/10.1371/journal.pone.0038849
URI: http://hdl.handle.net/2445/36389
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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