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Title: | North African populations carry the signature of admixture with Neandertals |
Author: | Sánchez Quinto, Federico Rodríguez Botigué, Laura Civit Vives, Sergi Arenas Solà, Concepción Ávila-Arcos, María C. Bustamante, Carlos D. Comas, David Lalueza Fox, Carles, 1965- |
Keywords: | ADN Paleobiologia Home de Neandertal Àfrica del Nord Paleobiologia evolutiva DNA Paleobiology Neanderthals Africa, North Evolutionary paleobiology |
Issue Date: | Oct-2012 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0047765 |
It is part of: | PLoS One, 2012, vol. 7, num. 10, p. e47765 |
URI: | http://hdl.handle.net/2445/43562 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0047765 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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