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|Title:||North African populations carry the signature of admixture with Neandertals|
|Author:||Sánchez Quinto, F.|
Rodríguez Botigué, L.
Civit Vives, Sergi
Arenas Solà, Concepción
Ávila-Arcos, M. C.
Bustamante, C. D.
Lalueza Fox, Carles, 1965-
Home de Neandertal
Àfrica del Nord
|Publisher:||Public Library of Science (PLoS)|
|Abstract:||One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.|
|Note:||Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0047765|
|It is part of:||PLoS One, 2012, vol. 7, num. 10, p. e47765|
|Appears in Collections:||Articles publicats en revistes (Genètica, Microbiologia i Estadística)|
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