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Title: North African populations carry the signature of admixture with Neandertals
Author: Sánchez Quinto, F.
Rodríguez Botigué, L.
Civit Vives, Sergi
Arenas Solà, Concepción
Ávila-Arcos, M. C.
Bustamante, C. D.
Comas, D.
Lalueza Fox, Carles, 1965-
Keywords: ADN
Home de Neandertal
Àfrica del Nord
Paleobiologia evolutiva
Africa, North
Evolutionary paleobiology
Issue Date: Oct-2012
Publisher: Public Library of Science (PLoS)
Abstract: One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, num. 10, p. e47765
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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