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Title: Task-induced deactivation from rest extends beyond the default mode brain network
Author: Harrison, Ben J.
Pujol Nuez, Jesús
Contreras-Rodríguez, Oren
Soriano Mas, Carles
López Solá, Marina
Deus Yela, Juan
Ortiz, Hector
Blanco-Hinojo, Laura
Alonso Ortega, María del Pino
Hernàndez Ribas, Rosa
Cardoner, N. (Narcís)
Menchón Magriñá, José Manuel
Keywords: Cognició
Mapatge del cervell
Assaigs clínics
Brain mapping
Clinical trials
Issue Date: 2011
Publisher: Public Library of Science (PLoS)
Abstract: Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
Note: Reproducció del document publicat a: 10.1371/journal.pone.0022964
It is part of: PLoS One, 2011, vol. 6, num. 7, p. e22964
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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