Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/44119
Title: Understanding and modulating the competitive surface-adsorption of proteins through coarse-grained molecular dynamics simulations
Author: Vilaseca Mainar, Pol
Dawson, Kenneth A.
Franzese, Giancarlo
Keywords: Nanopartícules
Plasma sanguini
Biomolècules
Proteïnes
Adsorció
Química de superfícies
Nanoparticles
Blood plasma
Biomolecules
Proteins
Adsorption
Surface chemistry
Issue Date: 16-Apr-2013
Publisher: Royal Society of Chemistry
Abstract: It is now well accepted that cellular responses to materials in a biological medium reflect greatly the adsorbed biomolecular layer, rather than the material itself. Here, we study by molecular dynamics simulations the competitive protein adsorption on a surface (Vroman effect), i.e. the non-monotonic behavior of the amount of protein adsorbed on a surface in contact with plasma as functions of contact time and plasma concentration. We find a complex behavior, with regimes during which small and large proteins are not necessarily competing between them, but are both competing with others in solution ("cooperative" adsorption). We show how the Vroman effect can be understood, controlled and inverted.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1039/c3sm50220a
It is part of: Soft Matter, 2013
Related resource: http://dx.doi.org/10.1039/c3sm50220a
URI: http://hdl.handle.net/2445/44119
ISSN: 1744-683X
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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