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Title: Understanding and modulating the competitive surface-adsorption of proteins through coarse-grained molecular dynamics simulations
Author: Vilaseca Mainar, Pol
Dawson, Kenneth A.
Franzese, Giancarlo
Keywords: Nanopartícules
Plasma sanguini
Química de superfícies
Blood plasma
Surface chemistry
Issue Date: 16-Apr-2013
Publisher: Royal Society of Chemistry
Abstract: It is now well accepted that cellular responses to materials in a biological medium reflect greatly the adsorbed biomolecular layer, rather than the material itself. Here, we study by molecular dynamics simulations the competitive protein adsorption on a surface (Vroman effect), i.e. the non-monotonic behavior of the amount of protein adsorbed on a surface in contact with plasma as functions of contact time and plasma concentration. We find a complex behavior, with regimes during which small and large proteins are not necessarily competing between them, but are both competing with others in solution ("cooperative" adsorption). We show how the Vroman effect can be understood, controlled and inverted.
Note: Versió postprint del document publicat a:
It is part of: Soft Matter, 2013
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ISSN: 1744-683X
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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