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|Title:||Childhood adversity and psychosis: examinig whether the association is due to genetic confounding using a monozygotic twin differences approach|
|Author:||Alemany Sierra, Silvia|
Van Winkel, R.
Gastó Ferrer, Cristóbal
Fañanás Saura, Lourdes
|Publisher:||Elsevier Masson SAS|
|Abstract:||Purpose: To test whether the association between childhood adversity and positive and negative psychotic experiences is due to genetic confounding. Method: Childhood adversity and psychotic experiences were assessed in a sample of 226 twins from the general population. A monozygotic (MZ) twin differences approach was used to assess possible genetic confounding. Results: In the whole sample, childhood adversity was significantly associated with positive (β =.45; SE=.16; p=.008) and negative psychotic experiences (β=.77; SE=.18; p<.01). Within-pair MZ twin differences in exposure to childhood adversity were significantly associated with differences in positive (β =.71; SE=.29; p=.016) and negative psychotic experiences (β =.98; SE=.38; p=.014) in a subsample of 86 MZ twin pairs. Conclusions: Individuals exposed to childhood adversity are more likely to report psychotic experiences. Furthermore, our findings indicate that unique environmental effects of childhood adversity contribute to the development of psychotic experiences.|
|Note:||Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.eurpsy.2012.03.001|
|It is part of:||European Psychiatry, 2013, vol. 28, num. 4, p. 207-212|
|Appears in Collections:||Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)|
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