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Title: Childhood adversity and psychosis: examinig whether the association is due to genetic confounding using a monozygotic twin differences approach
Author: Alemany Sierra, Silvia
Goldberg, Ximena
Van Winkel, R.
Gastó Ferrer, Cristóbal
Peralta, V.
Fañanás Saura, Lourdes
Keywords: Genètica
Psicopatologia infantil
Infants maltractats
Child psychopathology
Abused children
Issue Date: May-2013
Publisher: Elsevier Masson SAS
Abstract: Purpose: To test whether the association between childhood adversity and positive and negative psychotic experiences is due to genetic confounding. Method: Childhood adversity and psychotic experiences were assessed in a sample of 226 twins from the general population. A monozygotic (MZ) twin differences approach was used to assess possible genetic confounding. Results: In the whole sample, childhood adversity was significantly associated with positive (β =.45; SE=.16; p=.008) and negative psychotic experiences (β=.77; SE=.18; p<.01). Within-pair MZ twin differences in exposure to childhood adversity were significantly associated with differences in positive (β =.71; SE=.29; p=.016) and negative psychotic experiences (β =.98; SE=.38; p=.014) in a subsample of 86 MZ twin pairs. Conclusions: Individuals exposed to childhood adversity are more likely to report psychotic experiences. Furthermore, our findings indicate that unique environmental effects of childhood adversity contribute to the development of psychotic experiences.
Note: Versió postprint del document publicat a:
It is part of: European Psychiatry, 2013, vol. 28, num. 4, p. 207-212
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ISSN: 0924-9338
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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