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Title: Nanocharacterization of Soft Biological Samples in Shear Mode with Quartz Tuning Fork Probes
Author: Otero Díaz, Jorge
González Claramonte, Laura
Puig i Vidal, Manuel
Keywords: Microscòpia de força atòmica
Atomic force microscopy
Issue Date: 24-Mar-2012
Publisher: MDPI Publishing
Abstract: Quartz tuning forks are extremely good resonators and their use is growing in scanning probe microscopy. Nevertheless, only a few studies on soft biological samples have been reported using these probes. In this work, we present the methodology to develop and use these nanosensors to properly work with biological samples. The working principles, fabrication and experimental setup are presented. The results in the nanocharacterization of different samples in different ambients are presented by using different working modes: amplitude modulation with and without the use of a Phase-Locked Loop (PLL) and frequency modulation. Pseudomonas aeruginosa bacteria are imaged in nitrogen using amplitude modulation. Microcontact printed antibodies are imaged in buffer using amplitude modulation with a PLL. Finally, metastatic cells are imaged in air using frequency modulation.
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It is part of: Sensors, 2012, vol. 12, p. 4803-4819
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ISSN: 1424-8220
Appears in Collections:Articles publicats en revistes (Electrònica)

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