Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/48627
Title: Regio- and stereoselective microwave-assisted synthesis of 5-alkyl-4-alkenyl-4-phenyl-1,3-oxazolidin-2-ones
Author: Amador Palomar, Marta
Ariza Piquer, Xavier
Boyer, Jérémie
D'Andrea Rodríguez-Vida, Lucía
García Gómez, Jordi
Granell Sanvicente, Jaime Ramón
Keywords: Pal·ladi (Element químic)
Catàlisi
Níquel
Microones
Estereoquímica
Palladium
Catalysis
Nickel
Microwaves
Stereochemistry
Issue Date: 2010
Publisher: Elsevier Ltd
Abstract: Chiral symmetrical alk-2-yne-1,4-diols have been stereoselectively transformed into 5-alkyl-4-alkenyl-4-phenyl-1,3-oxazolidin- 2-ones, which are precursors of quaternary α-amino β-hydroxy acids. The key step was the cyclization of the bis(tosylcarbamates) of 2- phenylalk-2-yne-1,4-diols, easily obtained from the starting chiral diols. These cyclizations were accomplished with complete regioselectivity and up to 92:8 dr in the presence of catalytic amounts of Ni(0) or Pd (II) derivatives under microwave heating.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.tetlet.2009.12.036
It is part of: Tetrahedron Letters, 2010, vol. 51, num. 6, p. 935-938
Related resource: http://dx.doi.org/10.1016/j.tetlet.2009.12.036
URI: http://hdl.handle.net/2445/48627
ISSN: 0040-4039
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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