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http://hdl.handle.net/2445/48632| Title: | Stereoselective Synthesis of (-)-Spicigerolide |
| Author: | Georges, Yohan Ariza Piquer, Xavier García Gómez, Jordi |
| Keywords: | Plantes Botànica mèdica Citotoxicitat per mediació cel·lular Càncer Estereoquímica Productes naturals Síntesi orgànica Plants Medical botany Cell-mediated cytotoxicity Cancer Stereochemistry Natural products Organic synthesis |
| Issue Date: | 2009 |
| Publisher: | American Chemical Society |
| Abstract: | (-)-Spicigerolide was enantioselectively synthesized from a protected (S)-lactaldehyde. The synthesis of the polyacetylated framework relied on two Zn-mediated stereoselective additions of alkynes to aldehydes as well as a regiocontrolled [3,3]-sigmatropic rearrangement of an allylic acetate. The pyranone moiety was constructed via ring-closing metathesis. |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1021/jo8025753 |
| It is part of: | Journal of Organic Chemistry, 2009, vol. 74, num. 5, p. 2008-2012 |
| URI: | http://hdl.handle.net/2445/48632 |
| Related resource: | http://dx.doi.org/10.1021/jo8025753 |
| ISSN: | 0022-3263 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 565900.pdf | 376.41 kB | Adobe PDF | View/Open |
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