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Title: High-resolution mass spectrometry applied to the study of metabolome modifications in various chicken tissues after amoxicillin administration
Author: Hermo Outeiral, Ma. del Pilar
Saurina, Javier
Barbosa Torralbo, José
Barrón Bueno, Dolores
Keywords: Amoxicil·lina
Anàlisi multivariable
Espectrometria de masses
Qualitat dels aliments
Multivariate analysis
Mass spectrometry
Food quality
Issue Date: 2014
Publisher: Elsevier B.V.
Abstract: The performance of high resolution accurate mass spectrometry (HRMS) operating in full scan MS mode was investigated for the quantitative determination of amoxicillin (AMX) as well as qualitative analysis of metabolomic profiles in tissues of medicated chickens. The metabolomic approach was exploited to compile analytical information on changes in the metabolome of muscle, kidney and liver from chickens subjected to a pharmacological program with AMX. Data consisting of m/z features taken throughout the entire chromatogram were extracted and filtered to be treated by Principal Component Analysis. As a result, it was found that medicated and non-treated animals were clearly clustered in distinct groups. Besides, the multivariate analysis revealed some relevant mass features contributing to this separation. In this context, recognizing those potential markers of each chicken class was a priority research for both metabolite identification and, obviously, evaluation of food quality and health effects associated to food consumption.
Note: Versió postprint del document publicat a:
It is part of: Food Chemistry, 2014, vol. 153, p. 405-413
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ISSN: 0308-8146
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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