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Title: Comparison of three analytical methods for the determination of quinolones in pig muscle samples
Author: Jiménez-Díaz, Inmaculada
Hermo Outeiral, Ma. del Pilar
Ballesteros, Óscar
Zafra-Gómez, Alberto
Barrón Bueno, Dolores
Barbosa Torralbo, José
Navalón, Alberto
Keywords: Cromatografia de líquids
Espectrometria de masses
Liquid chromatography
Mass spectrometry
Quinolone antibacterial agents
Issue Date: 2013
Publisher: Springer Verlag
Abstract: This work presents a comparison between three analytical methods developed for the simultaneous determination of eight quinolones regulated by the European Union (marbofloxacin, ciprofloxacin, danofloxacin, enrofloxacin, difloxacin, sarafloxacin, oxolinic acid and flumequine) in pig muscle, using liquid chromatography with fluorescence detection (LC-FD), liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The procedures involve an extraction of the quinolones from the tissues, a step for clean-up and preconcentration of the analytes by solid-phase extraction and a subsequent liquid chromatographic analysis. The limits of detection of the methods ranged from 0.1 to 2.1 ng g−1 using LC-FD, from 0.3 to 1.8 using LC-MS and from 0.2 to 0.3 using LC-MS/MS, while inter- and intra-day variability was under 15 % in all cases. Most of those data are notably lower than the maximum residue limits established by the European Union for quinolones in pig tissues. The methods have been applied for the determination of quinolones in six different commercial pig muscle samples purchased in different supermarkets located in the city of Granada (south-east Spain).
Note: Versió postprint del document publicat a:
It is part of: Chromatographia, 2013, vol. 76, num. 11-12, p. 707-713
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ISSN: 0009-5893
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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