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Title: Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
Author: Sabater Martínez, David
Arriarán, Sofía
Romero Romero, María del Mar
Agnelli, Silvia
Fernández López, José Antonio
Remesar Betlloch, Xavier
Alemany, Marià, 1946-
Keywords: Teixit adipós
Cultius cel·lulars humans
Adipose tissues
Human cell culture
Issue Date: 13-Jan-2014
Publisher: Nature Publishing Group
Abstract: White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lactate with only part of it being used to synthesize fat. Cultured adipocytes were largely anaerobic, but this was not a Warburg-like process. It is speculated that the massive production of lactate, is a process of defense of the adipocyte, used to dispose of excess glucose. This way, the adipocyte exports glucose carbon (and reduces the problem of excess substrate availability) to the liver, but the process may be also a mechanism of short-term control of hyperglycemia. The in vivo data obtained from adipose tissue of male rats agree with this interpretation.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2014, num. 4
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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