Please use this identifier to cite or link to this item:
Title: Nitrogen metabolism in Zucker rats is affected by moderate reduction, but not by moderate incerase in dietary protein
Author: Rafecas Martínez, Magdalena
Remesar Betlloch, Xavier
Keywords: Dieta
Proteïnes en nutrició humana
Nitrogen en l'organisme
Rates (Animals de laboratori)
Proteins in human nutrition
Amino acids
Nitrogen in the body
Rats as laboratory animals
Issue Date: 30-Nov-2012
Publisher: Bentham Open
Abstract: Marked changes in the content of protein in the diet affects the rat"s pattern of growth, but there is not any data on the effects to moderate changes. Here we used a genetically obese rat strain (Zucker) to examine the metabolic modifications induced to moderate changes in the content of protein of diets, doubling (high-protein (HP): 30%) or halving (low-protein (LP): 8%) the content of protein of reference diet (RD: 16%). Nitrogen, energy balances, and amino acid levels were determined in lean (L) and obese (O) animals after 30 days on each diet. Lean HP (LHP) animals showed higher energy efficiency and amino acid catabolism but maintained similar amino acid accrual rates to the lean RD (LRD) group. Conversely, the lean LP (LLP) group showed a lower growth rate, which was compensated by a relative increase in fat mass. Furthermore, these animals showed greater efficiency accruing amino acids. Obesity increased amino acid catabolism as a result of massive amino acid intake; however, obese rats maintained protein accretion rates, which, in the OHP group, implied a normalization of energy efficiency. Nonetheless, the obese OLP group showed the same protein accretion pattern as in lean animals (LLP). In the base of our data, concluded that the Zucker rats accommodate their metabolism to support moderates increases in the content of protein in the diet, but do not adjust in the same way to a 50% decrease in content of protein, as shown by an index of growth reduced, both in lean and obese rats.
Note: Reproducció del document publicat a:
It is part of: The Open Obesity Journal, 2012, vol. 4, p. 44-50
Related resource:
ISSN: 1876-8237
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Files in This Item:
File Description SizeFormat 
618444.pdf257.55 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons