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Title: Evidence of an efflux pump in Serratia marcescens
Author: Berlanga Herranz, Mercedes
Vázquez, J. L.
Borrell Hernández, Jordi
Montero Barrientos, Ma. Teresa
Viñas, Miquel
Keywords: Resistència als medicaments
Serratia marcescens
Medicaments antibacterians
Drug resistance
Serratia marcescens
Issue Date: 7-Jul-2000
Publisher: Mary Ann Liebert, Inc.
Abstract: Spontaneous mutants resistant to fluoroquinolones were obtained by exposing Serratia marcescens NIMA (wild-type strain) to increasing concentrations of ciprofloxacin both in liquid and on solid media. Frequencies of mutation ranged from 10-7 to 10-9. Active expulsion of antibiotic was explored as a possible mechanism of resistance in mutants as well as changes in topoisomerase target genes. The role of extrusion mechanisms in determining the emergence of multidrug-resistant bacteria was also examined. Mutants resistant to high concentrations of fluoroquinolones had a single mutation in their gyrA QRDR sequences, whereas the moderate resistance in the rest of mutants was due to extrusion of the drug
Note: Reproducció del document publicat a:
It is part of: Microbial Drug Resistance, 2000, vol. 6, num. 2, p. 111-117
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ISSN: 1076-6294
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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