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Title: The role of Serratia marcescens porins in antibiotic resistance
Author: Ruiz España, Neus
Montero Barrientos, Ma. Teresa
Borrell Hernández, Jordi
Viñas, Miquel
Keywords: Resistència als medicaments
Medicaments antibacterians
Serratia marcescens
Drug resistance
Antibacterial agents
Serratia marcescens
Issue Date: Aug-2003
Publisher: Mary Ann Liebert, Inc.
Abstract: The outer membrane permeability of Serratia marcescens was studied by comparing porin-deficient mutants with their parental strains. Omp1-deficient strains were selected by moxalactam resistance, whereas mutants lacking the Omp2 porin were obtained by experimental infection with the SMP2 phage, whose primary receptor is the Omp2 porin. The role of porins was demonstrated in quinolone accumulation assays, where semi-quantitative differences in accumulation were observed. Permeability coefficients to cephaloridine of Omp1 mutants were determined and compared with those of the parental strain. The clinical isolates S. marcescens HCPR1 and 866 showed 30- to 200-fold reduced permeability coefficients when Omp1 porin was absent
Note: Reproducció del document publicat a:
It is part of: Microbial Drug Resistance, 2003, vol. 9, num. 3, p. 257-264
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ISSN: 1076-6294
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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