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http://hdl.handle.net/2445/56045
Title: | Synthesis and antitumor activity of mechercharmycin A analogues |
Author: | Hernández Romero, Delia Altuna, Marta Cuevas, Carmen Aligué i Alemany, Rosa Maria Albericio Palomera, Fernando Álvarez Domingo, Mercedes |
Keywords: | Compostos heterocíclics Medicaments antineoplàstics Síntesi de pèptids Espectroscòpia de ressonància magnètica nuclear Heterocyclic compounds Antineoplastic agents Peptide synthesis Nuclear magnetic resonance spectroscopy |
Issue Date: | 3-Sep-2008 |
Publisher: | American Chemical Society |
Abstract: | Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1021/jm800513w |
It is part of: | Journal of Medicinal Chemistry, 2008, vol. 51, num. 18, p. 5722-5730 |
URI: | http://hdl.handle.net/2445/56045 |
Related resource: | http://dx.doi.org/10.1021/jm800513w |
ISSN: | 0022-2623 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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