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Title: Synthesis and antitumor activity of mechercharmycin A analogues
Author: Hernández, Delia
Altuna, Marta
Cuevas, Carmen
Aligué i Alemany, Rosa Maria
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Compostos heterocíclics
Medicaments antineoplàstics
Síntesi de pèptids
Espectroscòpia de ressonància magnètica nuclear
Heterocyclic compounds
Antineoplastic agents
Peptide synthesis
Nuclear magnetic resonance spectroscopy
Issue Date: 3-Sep-2008
Publisher: American Chemical Society
Abstract: Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected.
Note: Versió postprint del document publicat a:
It is part of: Journal of Medicinal Chemistry, 2008, vol. 51, num. 18, p. 5722-5730
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ISSN: 0022-2623
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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