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Title: The mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease
Author: Urpí Sardà, Mireia
Casas, Rosa
Chiva Blanch, Gemma
Romero-Mamani, Edwin Saúl
Valderas Martínez, Palmira
Salas Salvadó, Jordi
Covas Planells, María Isabel
Toledo, Estefanía
Andrés Lacueva, Ma. Cristina
Llorach, Rafael
García Arellano, Ana
Bulló, Mònica
Ruiz-Gutiérrez, Valentina
Lamuela Raventós, Rosa Ma.
Estruch Riba, Ramon
Keywords: Malalties cardiovasculars
Cuina mediterrània
Suplements nutritius
Olis vegetals
Fruita seca
Cardiovascular diseases
Mediterranean cooking
Dietary supplements
Vegetable oils
Dried fruit
Issue Date: 25-Apr-2012
Publisher: American Society for Nutrition
Abstract: Adherence to aMediterranean diet (MD) is associated with a reduced risk of coronary heart disease. However, themolecular mechanisms involved are not fully understood. The aim of this studywas to compare the effects of 2MD with those of a lowfat- diet (LFD) on circulating inflammatory biomarkers related to atherogenesis. A total of 516 participants included in the PreventionwithMediterraneanDiet Studywere randomized into 3 intervention groups [MD supplementedwith virgin olive oil (MD-VOO); MD supplemented with mixed nuts (MD-Nuts); and LFD]. At baseline and after 1 y, participants completed FFQ and adherence to MD questionnaires, and plasma concentrations of inflammatory markers including intercellular adhesion molecule-1(ICAM-1), IL-6, and 2 TNF receptors (TNFR60 and TNFR80) were measured by ELISA. At 1 y, the MD groups had lower plasma concentrations of IL-6, TNFR60, and TNFR80 (P , 0.05), whereas ICAM-1, TNFR60, and TNFR80 concentrations increased in the LFD group (P , 0.002). Due to between-group differences, participants in the 2 MD groups had lower plasma concentrations of ICAM-1, IL-6, TNFR60, and TNFR80 compared to those in the LFD group (P # 0.028). When participants were categorized in tertiles of 1-y changes in the consumption of selected foods, those in the highest tertile of virgin olive oil (VOO) and vegetable consumption had a lower plasma TNFR60 concentration compared with those in tertile 1 (P,0.02).Moreover, the only changes in consumption thatwere associated with 1-y changes in the geometricmean TNFR60 concentrations were those of VOO and vegetables (P = 0.01). This study suggests that a MD reduces TNFR concentrations in patients at high cardiovascular risk.
It is part of: Journal of Nutrition, 2012, vol. 142, num. 6, p. 1019-1025
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ISSN: 0022-3166
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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