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http://hdl.handle.net/2445/58563
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DC Field | Value | Language |
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dc.contributor.author | Corella Piquer, Dolores | - |
dc.contributor.author | González, José Ignacio | - |
dc.contributor.author | Bulló, Mònica | - |
dc.contributor.author | Carrasco, Paula | - |
dc.contributor.author | Portolés, Olga | - |
dc.contributor.author | Díez Espino, Javier | - |
dc.contributor.author | Covas Planells, María Isabel | - |
dc.contributor.author | Ruiz-Gutiérrez, Valentina | - |
dc.contributor.author | Gómez Gracia, Enrique | - |
dc.contributor.author | Arós, Fernando | - |
dc.contributor.author | Fiol Sala, Miguel | - |
dc.contributor.author | Conde Herrera, Manuel | - |
dc.contributor.author | Santos, José Manuel | - |
dc.contributor.author | Sáez Tormo, Guillermo | - |
dc.contributor.author | Lamuela Raventós, Rosa Ma. | - |
dc.contributor.author | Lahoz, Carlos | - |
dc.contributor.author | Vinyoles, Ernest | - |
dc.contributor.author | Ros Rahola, Emilio | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.date.accessioned | 2014-10-14T06:29:52Z | - |
dc.date.issued | 2008-12-03 | - |
dc.identifier.issn | 0022-3166 | - |
dc.identifier.uri | http://hdl.handle.net/2445/58563 | - |
dc.description.abstract | Inflammation is involved in cardiovascular diseases. Some studies have found that the Mediterranean diet (MD) can reduce serum concentrations of inflammation markers. However, none of these studies have analyzed the influence of genetic variability in such a response. Our objective was to study the effect of the -765G.C polymorphism in the cyclooxygenase-2 (COX-2) gene and the -174G.C polymorphism in the interleukin-6 (IL-6) gene on serum concentrations of IL-6, C-reactive protein, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 as well as their influence on the response toa nutritional interventionwithMD.An intervention study ina high cardiovascular riskMediterranean population (314 men and 407 women) was undertaken. Participants were randomly assigned to consume a low-fat control diet or a MD supplementedwith virgin olive oil ornuts.Measureswereobtained at baseline and after a 3-mointervention period.At baseline, the COX-2 -765G.C polymorphismwas associated with lower serum IL-6 (5.85 6 4.82 in GG vs. 4.74 6 4.14 ng/L in C-allele carriers; P ¼ 0.002) and ICAM-1 (265.8 6 114.8 in GG vs. 243.0 6 107.1 mg/L in C-carriers; P ¼ 0.018) concentrations. These differences remained significant aftermultivariate adjustment. The IL-6 -174G.C polymorphism was associatedwith higher (CC vs. G-carriers) serumICAM-1concentrations in bothmenandwomenandwithhigherserumIL-6 concentrations inmen.Following the dietary intervention, no significant gene x diet interactions were found. In conclusion, although COX-2 -765G.C and IL-6 -174G.C polymorphismswere associatedwith inflammation, consuming aMD(either supplemented with virgin olive oil or nuts) reduced the concentration of inflammation markers regardless of these polymorphisms. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Nutrition | - |
dc.relation.isformatof | http://dx.doi.org/10.3945/jn.108.093054 | - |
dc.relation.ispartof | Journal of Nutrition, 2008, vol. 139, num. 1, p. 128-134 | - |
dc.relation.uri | http://dx.doi.org/10.3945/jn.108.093054 | - |
dc.rights | (c) American Society for Nutrition, 2008 | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Cuina mediterrània | - |
dc.subject.classification | Suplements nutritius | - |
dc.subject.classification | Olis vegetals | - |
dc.subject.classification | Oli d'oliva | - |
dc.subject.classification | Fruita seca | - |
dc.subject.classification | Polimorfisme genètic | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Interleucines | - |
dc.subject.other | Cardiovascular diseases | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Mediterranean cooking | - |
dc.subject.other | Dietary supplements | - |
dc.subject.other | Vegetable oils | - |
dc.subject.other | Olive oil | - |
dc.subject.other | Dried fruit | - |
dc.subject.other | Genetic polymorphisms | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Interleukins | - |
dc.title | Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts | - |
dc.type | info:eu-repo/semantics/article | - |
dc.identifier.idgrec | 621818 | - |
dc.date.updated | 2014-10-14T06:29:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | - |
dc.embargo.lift | 2099-01-01 | - |
dc.date.embargoEndDate | info:eu-repo/date/embargoEnd/2099-01-01 | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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621818.pdf | 689.51 kB | Adobe PDF | View/Open Request a copy |
Document embargat fins el 1-1-2099
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