Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/59143
Title: Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study.
Author: Córdova-Palomera, A.
Alemany Sierra, Silvia
Fatjó-Vilas, M.
Goldberg, Ximena
Leza, JC.
Nenadic, I
Fañanás Saura, Lourdes
Keywords: Neurologia
Memòria
ADN
Neurology
Memory
DNA
Issue Date: 2014
Publisher: Public Library of Science (PLoS)
Abstract: Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0103639
It is part of: PLoS One, 2014, vol. 9, num. 8
Related resource: http://dx.doi.org/10.1371/journal.pone.0103639
URI: http://hdl.handle.net/2445/59143
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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