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http://hdl.handle.net/2445/61471
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DC Field | Value | Language |
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dc.contributor.author | Merino Montero, Susana | - |
dc.contributor.author | Bouamama, Lamiaa | - |
dc.contributor.author | Knirel, Yuriy A. | - |
dc.contributor.author | Shenchenkova, Sofya N. | - |
dc.contributor.author | Regué Queralt, Miguel, 1953- | - |
dc.contributor.author | Tomàs Magaña, Juan | - |
dc.date.accessioned | 2015-01-19T10:13:18Z | - |
dc.date.available | 2015-01-19T10:13:18Z | - |
dc.date.issued | 2012-05-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/61471 | - |
dc.description.abstract | We previously reported that A. hydrophila GalU mutants were still able to produce UDP-glucose introduced as a glucose residue in their lipopolysaccharide core. In this study, we found the unique origin of this UDP-glucose from a branched α-glucan surface polysaccharide. This glucan, surface attached through the O-antigen ligase (WaaL), is common to the mesophilic Aeromonas strains tested. The Aeromonas glucan is produced by the action of the glycogen synthase (GlgA) and the UDP-Glc pyrophosphorylase (GlgC), the latter wrongly indicated as an ADP-Glc pyrophosphorylase in the Aeromonas genomes available. The Aeromonas glycogen synthase is able to react with UDP or ADP-glucose, which is not the case of E. coli glycogen synthase only reacting with ADP-glucose. The Aeromonas surface glucan has a role enhancing biofilm formation. Finally, for the first time to our knowledge, a clear preference on behalf of bacterial survival and pathogenesis is observed when choosing to produce one or other surface saccharide molecules to produce (lipopolysaccharide core or glucan). | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0035707 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 5, p. e35707 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0035707 | - |
dc.rights | cc-by (c) Merino Montero, Susana et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | - |
dc.subject.classification | Bacteris | - |
dc.subject.classification | Glucosa | - |
dc.subject.classification | Polisacàrids | - |
dc.subject.classification | Enzims | - |
dc.subject.classification | Reacció en cadena de la polimerasa | - |
dc.subject.other | Bacteria | - |
dc.subject.other | Glucose | - |
dc.subject.other | Polysaccharides | - |
dc.subject.other | Enzymes | - |
dc.subject.other | Polymerase chain reaction | - |
dc.title | Aeromonas surface glucan attached throught the O-antigen ligase represents a new way to obtain UDP-Glucose | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 614550 | - |
dc.date.updated | 2015-01-15T18:02:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22563467 | - |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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614550.pdf | 986.27 kB | Adobe PDF | View/Open |
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