Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/65098
Title: A potential role for a genetic variation of AKAP5 in human aggression and anger control
Author: Richter, S.
Gorny, X.
Marco Pallarés, Josep
Krämer, U. M.
Machts, J.
Barman, A.
Bernstein, H. G.
Schüle, Rebecca
Schöls, L.
Rodríguez Fornells, Antoni
Reissner, C.
Wüstenberg, T.
Heinze, H. J.
Gundelfinger, E. D.
Düzel, E.
Münte, T.F.
Seidenbecher, C. I.
Schott, B. H.
Keywords: Proteïnes quinases
Agressivitat
Ira
Radiologia mèdica
Protein kinases
Aggressiveness
Anger
Medical radiology
Issue Date: 2011
Publisher: Frontiers Media
Abstract: The A-kinase-anchoring protein 5 (AKAP5), a post-synaptic multi-adaptor molecule that binds G-protein-coupled receptors and intracellular signaling molecules has been implicated in emotional processing in rodents, but its role in human emotion and behavior is up to now still not quite clear. Here, we report an association of individual differences in aggressive behavior and anger expression with a functional genetic polymorphism (Pro100Leu) in the human AKAP5 gene. Among a cohort of 527 young, healthy individuals, carriers of the less common Leu allele (15.6% allele frequency) scored significantly lower in the physical aggression domain of the Buss and Perry Aggression Questionnaire and higher in the anger control dimension of the state-trait anger expression inventory. In a functional magnetic resonance imaging experiment we could further demonstrate that AKAP5 Pro100Leu modulates the interaction of negative emotional processing and executive functions. In order to investigate implicit processes of anger control, we used the well-known flanker task to evoke processes of action monitoring and error processing and added taskirrelevant neutral or angry faces in the background of the flanker stimuli. In line with our predictions, Leu carriers showed increased activation of the anterior cingulate cortex (ACC) during emotional interference, which in turn predicted shorter reaction times and might be related to stronger control of emotional interference. Conversely, Pro homozygotes exhibited increased orbitofrontal cortex (OFC) activation during emotional interference, with no behavioral advantage. Immunohistochemistry revealed AKAP5 expression in post mortem human ACC and OFC. Our results suggest that AKAP5 Pro100Leu contributes to individual differences in human aggression and anger control. Further research is warranted to explore the detailed role of AKAP5 and its gene product in human emotion processing.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fnhum.2011.00175
It is part of: Frontiers in Human Neuroscience, 2011, vol. 5, num. 175, p. 1-14
Related resource: http://dx.doi.org/10.3389/fnhum.2011.00175
URI: http://hdl.handle.net/2445/65098
ISSN: 1662-5161
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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