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Title: Noradrenergic stimulation enhances human action monitoring
Author: Riba, J.
Rodríguez Fornells, Antoni
Morte, A.
Münte, T. F.
Barbanoj, M. J.
Keywords: Potencials evocats (Electrofisiologia)
Escorça cerebral
Conducta (Psicologia)
Evoked potentials (Electrophysiology)
Cerebral cortex
Human behavior
Issue Date: 2005
Publisher: The Society for Neuroscience
Abstract: Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by eventrelated brain potentials, was examined. After the administration of a placebo or the selective 2 -adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleus<br>noradrenaline system exerts a rather specific effect on human action monitoring.
Note: Reproducció del document publicat a:
It is part of: Journal of Neuroscience, 2005, vol. 25, num. 17, p. 4370-4374
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ISSN: 0270-6474
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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