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|Title:||Noradrenergic stimulation enhances human action monitoring|
Rodríguez Fornells, Antoni
Münte, T. F.
Barbanoj, M. J.
|Keywords:||Potencials evocats (Electrofisiologia)|
Evoked potentials (Electrophysiology)
|Publisher:||The Society for Neuroscience|
|Abstract:||Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by eventrelated brain potentials, was examined. After the administration of a placebo or the selective 2 -adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleus<br>noradrenaline system exerts a rather specific effect on human action monitoring.|
|Note:||Reproducció del document publicat a: http://dx.doi.org/10.1523/JNEUROSCI.4437-04.2005|
|It is part of:||Journal of Neuroscience, 2005, vol. 25, num. 17, p. 4370-4374|
|Appears in Collections:||Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)|
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