Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/66118
Title: (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
Author: Vázquez Fresno, Rosa
Llorach, Rafael
Alcaro, Francesca
Rodríguez Martínez, Miguel Ángel
Vinaixa Crevillent, Maria
Chiva Blanch, Gemma
Estruch Riba, Ramon
Correig Blanchar, Xavier
Andrés Lacueva, Ma. Cristina
Keywords: Vi
Consum d'alcohol
Metabolisme
Malalties cardiovasculars
Ressonància magnètica nuclear
Marcadors bioquímics
Metabòlits
Wine
Drinking of alcoholic beverages
Metabolism
Cardiovascular diseases
Nuclear magnetic resonance
Biochemical markers
Metabolites
Issue Date: Aug-2012
Publisher: Wiley-VCH
Abstract: Moderate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high cardiovascular risk factors followed three dietary interventions (28 days): dealcoholized red wine (RWD) (272mL/day, polyphenol control), alcoholized red wine (RWA) (272mL/day) and gin (GIN) (100mL/day, alcohol control). After each period, 24-h urine samples were collected and analyzed by (1) H-NMR. According to the results of a one-way ANOVA, significant markers were grouped in four categories: alcohol-related markers (ethanol); gin-related markers; wine-related markers; and gut microbiota markers (hippurate and 4-hydroxphenylacetic acid). Wine metabolites were classified into two groups; first, metabolites of food metabolome: tartrate (RWA and RWD), ethanol, and mannitol (RWA); and second, biomarkers that relates to endogenous modifications after wine consumption, comprising branched-chain amino acid (BCAA) metabolite (3-methyl-oxovalerate). Additionally, a possible interaction between alcohol and gut-related biomarkers has been identified. To our knowledge, this is the first time that this approach has been applied in a nutritional intervention with red wine. The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1002/elps.201100646
It is part of: Electrophoresis, 2012, vol. 33, num. 15, p. 2345-2354
Related resource: http://dx.doi.org/10.1002/elps.201100646
URI: http://hdl.handle.net/2445/66118
ISSN: 0173-0835
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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