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Title: Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
Author: Ardanuy Tisaire, María Carmen
Campa, Adela G. de la
García, Ernesto
Fenoll, Asunción
Calatayud, Laura
Cercenado, Emilia
Pérez Trallero, Emilio
Bouza, Emilio
Liñares Louzao, Josefina
Keywords: Pneumococs
Infeccions per pneumococs
Resistència als medicaments
Malalties de l'aparell respiratori
Malalties infeccioses
Streptococcus pneumonia
Pneumococcal Infections
Drug resistance
Respiratory diseases
Communicable diseases
Issue Date: Nov-2014
Publisher: Centers for Disease Control and Prevention
Abstract: Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.
Note: Reproducció del document publicat a:
It is part of: Emerging Infectious Diseases, 2014, vol. 20, num. 11, p. 1848-1856
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ISSN: 1080-6040
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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