Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/68245
Title: Understanding odor information segregation in the olfactory bulb by means of mitral and tufted cells
Author: Polese, Davide
Martinelli, Eugenio
Marco,Santiago
Di Natale, Corrado
Gutiérrez Gálvez, Agustín
Keywords: Olfacte
Olors
Xarxes neuronals (Informàtica)
Smell
Odors
Neural networks (Computer science)
Issue Date: 30-Oct-2014
Publisher: Public Library of Science (PLoS)
Abstract: Odor identification is one of the main tasks of the olfactory system. It is performed almost independently from the concentration of the odor providing a robust recognition. This capacity to ignore concentration information does not preclude the olfactory system from estimating concentration itself. Significant experimental evidence has indicated that the olfactory system is able to infer simultaneously odor identity and intensity. However, it is still unclear at what level or levels of the olfactory pathway this segregation of information occurs. In this work, we study whether this odor information segregation is performed at the input stage of the olfactory bulb: the glomerular layer. To this end, we built a detailed neural model of the glomerular layer based on its known anatomical connections and conducted two simulated odor experiments. In the first experiment, the model was exposed to an odor stimulus dataset composed of six different odorants, each one dosed at six different concentrations. In the second experiment, we conducted an odor morphing experiment where a sequence of binary mixtures going from one odor to another through intermediate mixtures was presented to the model. The results of the experiments were visualized using principal components analysis and analyzed with hierarchical clustering to unveil the structure of the high-dimensional output space. Additionally, Fisher's discriminant ratio and Pearson's correlation coefficient were used to quantify odor identity and odor concentration information respectively. Our results showed that the architecture of the glomerular layer was able to mediate the segregation of odor information obtaining output spiking sequences of the principal neurons, namely the mitral and external tufted cells, strongly correlated with odor identity and concentration, respectively. An important conclusion is also that the morphological difference between the principal neurons is not key to achieve odor information segregation.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0109716
It is part of: PLoS One, 2014, vol. 9, num. 10, p. e109716
Related resource: http://dx.doi.org/10.1371/journal.pone.0109716
URI: http://hdl.handle.net/2445/68245
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Electrònica)

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