Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/68349
Title: | Cells as active particles in asymmetric potentials: Motility under external gradients |
Author: | Comelles Pujadas, Jordi Caballero Vila, David Voituriez, Raphaël Hortigüela, Verónica Wollrab, Viktoria Godeau, Amélie Luise Samitier i Martí, Josep Martínez Fraiz, Elena Riveline, Daniel |
Keywords: | Migració cel·lular Nuclis cel·lulars Motilitat cel·lular Cell migration Cell nuclei Cell motility |
Issue Date: | 7-Oct-2014 |
Publisher: | Biophysical Society |
Abstract: | Cell migration is a crucial event during development and in disease. Mechanical constraints and chemical gradients can contribute to the establishment of cell direction, but their respective roles remain poorly understood. Using a microfabricated topographical ratchet, we show that the nucleus dictates the direction of cell movement through mechanical guidance by its environment. We demonstrate that this direction can be tuned by combining the topographical ratchet with a biochemical gradient of fibronectin adhesion. We report competition and cooperation between the two external cues. We also quantitatively compare the measurements associated with the trajectory of a model that treats cells as fluctuating particles trapped in a periodic asymmetric potential. We show that the cell nucleus contributes to the strength of the trap, whereas cell protrusions guided by the adhesive gradients add a constant tunable bias to the direction of cell motion. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1016/j.bpj.2014.08.001 |
It is part of: | Biophysical Journal, 2014, vol. 107, num. 7, p. 1513-1522 |
URI: | http://hdl.handle.net/2445/68349 |
Related resource: | http://dx.doi.org/10.1016/j.bpj.2014.08.001 |
ISSN: | 0006-3495 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) |
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