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Title: Cells as active particles in asymmetric potentials: Motility under external gradients
Author: Comelles, Jordi
Caballero Vila, David
Voituriez, Raphaël
Hortigüela, Verónica
Wollrab, Viktoria
Godeau, Amélie Luise
Samitier i Martí, Josep
Martínez Fraiz, Elena
Riveline, Daniel
Keywords: Migració cel·lular
Nuclis cel·lulars
Motilitat cel·lular
Cell migration
Cell nuclei
Cell motility
Issue Date: 7-Oct-2014
Publisher: Biophysical Society
Abstract: Cell migration is a crucial event during development and in disease. Mechanical constraints and chemical gradients can contribute to the establishment of cell direction, but their respective roles remain poorly understood. Using a microfabricated topographical ratchet, we show that the nucleus dictates the direction of cell movement through mechanical guidance by its environment. We demonstrate that this direction can be tuned by combining the topographical ratchet with a biochemical gradient of fibronectin adhesion. We report competition and cooperation between the two external cues. We also quantitatively compare the measurements associated with the trajectory of a model that treats cells as fluctuating particles trapped in a periodic asymmetric potential. We show that the cell nucleus contributes to the strength of the trap, whereas cell protrusions guided by the adhesive gradients add a constant tunable bias to the direction of cell motion.
Note: Reproducció del document publicat a:
It is part of: Biophysical Journal, 2014, vol. 107, num. 7, p. 1513-1522
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ISSN: 0006-3495
Appears in Collections:Articles publicats en revistes (Electrònica)

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