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Title: | Advances in immunosuppression for kidney transplantation: new strategies for preserving kidney function and reducing cardiovascular risk |
Other Titles: | Avances en la inmunosupresión para el trasplante renal. Nuevas estrategias para preservar la función renal y reducir el riesgo cardiovascular |
Author: | Bestard Matamoros, Oriol Campistol Plana, Josep M. Morales, José M. Sánchez-Fructuoso, A. Cabello, Mercedes Cabello, Virginia Pallardó, Luis M. Grinyó Boira, Josep M. |
Keywords: | Trasplantament renal Immunosupressors Factors de risc en les malalties Cor Kidney transplantation Immunosupressive agents Risk factors in diseases Heart |
Issue Date: | 1-Jan-2012 |
Publisher: | Elsevier España |
Abstract: | The development of new immunosuppressants for renal transplantation is aimed not only at improving short-term outcomes, but also at achieving better safety, cardiovascular, and metabolic profiles and at decreasing nephrotoxicity. Belatacept is a fusion protein that inhibits T cell activation by binding to CD80 and CD86 antigens. Clinical trials, particularly the BENEFIT and BENEFIT-EXT studies, have shown that belatacept preserves function and structure in renal grafts. The effects of belatacept provide long-term, sustained results, and the safety and efficacy of this drug have been demonstrated in cases of renal transplantation from expanded criteria donors. Compared to calcineurin inhibitors, belatacept is associated with a lower incidence of chronic allograft nephropathy and a more favourable cardiovascular and metabolic profile. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3265/Nefrologia.pre2012.Jan.11176 |
It is part of: | Nefrología, 2012, vol. 32, num. 3, p. 374-384 |
URI: | http://hdl.handle.net/2445/68648 |
Related resource: | http://dx.doi.org/10.3265/Nefrologia.pre2012.Jan.11176 |
ISSN: | 0211-6995 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
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