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Title: Mediterranean dietary pattern and depression: the PREDIMED randomized trial
Author: Sánchez-Villegas, Almudena
Martínez-González, Miguel Ángel, 1957-
Estruch Riba, Ramon
Salas Salvadó, Jordi
Corella Piquer, Dolores
Covas Planells, María Isabel
Arós, Fernando
Romaguera, Dora
Gómez-Gracia, E.
Lapetra, José
Pintó Sala, Xavier
Martínez, José Alfredo
Lamuela Raventós, Rosa Ma.
Ros Rahola, Emilio
Gea, Alfredo
Wärnberg, Julia
Serra Majem, Lluís
Keywords: Cuina mediterrània
Depressió psíquica
Hàbits alimentaris
Mediterranean cooking
Mental depression
Food habits
Issue Date: 20-Sep-2013
Publisher: BioMed Central
Abstract: Background: A few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention. Methods: This was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevención con Dieta Mediterránea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression. Results: We identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98). Conclusions: The result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2.
Note: Reproducció del document publicat a:
It is part of: Bmc Medicine, 2013, vol. 11, num. 208, p. 1-12
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ISSN: 1741-7015
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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